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Composite lymphoma in the anterior mediastinum: a case report and review of the literature

Guohua Yu1*, Lingling Kong2, Guimei Qu1, Qian Zhang2, Wei Wang1 and Lei Jiang1

Author Affiliations

1 Department of Pathology, Affiliated Yantai Yuhuangding Hospital, Medical College of Qingdao University, No.20, Yuhuangding East Road, Yantai, 264000, China

2 Department of Pathology, Binzhou Medical University, No.346, Guanhai Road, Yantai, 264003, China

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Diagnostic Pathology 2011, 6:60  doi:10.1186/1746-1596-6-60

Published: 6 July 2011


We recently encountered an unusual case of Composite lymphoma (CL) in the anterior mediastinum arising in a 37-year-old woman who presented initially with continuous pain in the right shoulder and chest. The woman had been suffered from continuous pain for three months before she went to our department of cardiovascular surgery. Chest computed tomography scan revealed the oval space-occupying lesion of anterior mediastinum. Surgery was performed and the disease was diagnosed pathologically as CL which composed of nodular sclerosing Hodgkin lymphoma and diffuse large B-cell lymphoma, via hematoxylin-eosin (H&E), immunohistochemical staining and in situ hybridization.

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Composite lymphoma; nodular sclerosing Hodgkin lymphoma; diffuse large B-cell lymphoma; immunohistochemistry; in situ hybridization