Open Access Open Badges Research

Morphometrical analysis of transbronchial cryobiopsies

Sergej Griff1*, Wim Ammenwerth2, Nicolas Schönfeld2, Torsten T Bauer2, Thomas Mairinger1, Torsten-Gerriet Blum2, Jens Kollmeier2 and Wolfram Grüning2

Author Affiliations

1 Institute of Pathology, HELIOS Klinikum Emil von Behring, Berlin, Germany

2 Department of Pneumology, Lungenklinik Heckeshorn, HELIOS Klinikum Emil von Behring, Berlin, Germany

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Diagnostic Pathology 2011, 6:53  doi:10.1186/1746-1596-6-53

Published: 16 June 2011


The recent introduction of bronchoscopically recovered cryobiopsy of lung tissue has opened up new possibilities in the diagnosis of neoplastic and non-neoplastic lung diseases in various aspects. Most notably the morphological diagnosis of peripheral lung biopsies promises to achieve a better yield with a high quality of specimens. To better understand this phenomenon, its diagnostic options and perspectives, this study morphometrically compares 15 cryobiopsies and 18 transbronchial forceps biopsies of peripheral lung tissue a priori without considering clinical hit ratio or integration of results in the clinical diagnostic processing. Cryotechnically harvested specimens were significantly larger (mean: 17.1 ± 10.7 mm2 versus 3.8 ± 4.0 mm2) and contained alveolar tissue more often. If present, the alveolar part in cryobiopsies exceeded the one of forceps biopsies. The alveolar tissue of crybiopsy specimens did not show any artefacts. Based on these results cryotechnique seems to open up new perspectives in bronchoscopic diagnosis of lung disease.