Table 3

Relationship analysis among XIAP/Smac immunoscore, apoptosis index, and clinicopathologic variables

n*

XIAP

P value

Smac

P value

AI

P value


Age

<50

49

2.3 ± 0.8

0.5 ± 0.6

1.3 ± 1.0

≥50

53

2.4 ± 0.8

0.586

0.3 ± 0.5

0.124

1.3 ± 1.1

0.903

Size

≤5 cm

77

2.4 ± 0.8

0.4 ± 0.6

1.3 ± 1.1

>5 cm

25

2.2 ± 0.9

0.386

0.4 ± 0.7

0.880

1.4 ± 1.0

0.849

LN status

N0

39

2.4 ± 0.8

0.4 ± 0.6

1.2 ± 0.8

N1-3

63

2.4 ± 0.8

0.969

0.4 ± 0.6

0.958

1.4 ± 1.2

0.282

Grade

I

25

2.5 ± 0.7

0.5 ± 0.6

1.6 ± 1.4

II-III

77

2.3 ± 0.8

0.444

0.4 ± 0.6

0.555

1.2 ± 0.9

0.227

ER

positive

39

2.3 ± 0.8

0.4 ± 0.6

1.2 ± 1.2

negative

63

2.4 ± 0.8

0.376

0.4 ± 0.6

0.659

1.4 ± 1.0

0.463

PR

positive

44

2.3 ± 0.8

0.5 ± 0.6

1.3 ± 0.8

negative

58

2.4 ± 0.8

0.669

0.3 ± 0.6

0.319

1.4 ± 1.2

0.779

HER2

positive

94

2.4 ± 0.8

0.4 ± 0.6

1.3 ± 0.9

negative

8

2.2 ± 0.8

0.544

0.0 ± 0.6

<0.0001

1.8 ± 2.1

0.611

XIAP-N

positive

44

2.6 ± 0.6

0.4 ± 0.6

1.3 ± 1.1

negative

58

2.2 ± 0.9

0.047

0.3 ± 0.6

0.540

1.4 ± 1.0

0.630


n*: number of cases. AI: apoptosis index. LN: lymph node. XIAP-C and XIAP-N denoted cytoplasmic immune staining score and nuclear labeling of XIAP, respectively. P-values (two sided) < 0.05 were highlighted in bold.

Zhang et al. Diagnostic Pathology 2011 6:49   doi:10.1186/1746-1596-6-49

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