Table 5

Promoter methylation in NSCLC-multivariable models assessing smoking history, histologic type, lymph node metastasis, and pleural indentation (ORand 95% CI)

Genes

Smoking history

SCC vs. ADC

Lymph node metastasis

Pleural indentation


CALCA

1.07 (0.40-2.88)

2.66 (0.85-8.32)

1.43 (0.46-4.41)

2.19 (0.61-7.79)


CDH1

0.98 (0.37-2.58)

6.77 (1.71-26.8)*

0.78 (0.29-2.13)

5.27 (1.27-21.9)*


DAPK1

0.83 (0.19-3.73)

10.7 (2.16-52.6)*

3.07 (0.32-29.4)

6.98 (1.06-45.8)*


IRX2

0.69 (0.26-1.83)

6.38 (1.77-23.0)*

0.85 (0.31-2.33)

3.89 (1.01-15.0)*


TIMP3

0.78 (0.30-2.02)

3.37 (1.03-11.0)*

1.75 (0.65-4.75)

2.66 (0.77-9.16)


PAX6

0.67 (0.21-2.08)

1.82 (0.50-6.57)

0.77 (0.25-2.38)

2.66 (0.58-12.3)


† OR: odds ratio with 95% confidence interval, adjusted for multiple comparisions.

* Significant at P < 0.05.

Ji et al. Diagnostic Pathology 2011 6:48   doi:10.1186/1746-1596-6-48

Open Data