Table 4 |
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|
Promoter methylation in NSCLC-univariate associations with clinicopathologic characteristics (OR† and 95% CI) |
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|
Genes |
Male vs. Female |
Age (per 10 years) |
Smoking history |
Pack-years1 |
SCC vs. ADC |
|
|
|||||
|
CALCA |
0.73 (0.28-1.90) |
0.94 (0.58-1.52) |
1.43 (0.57-3.57) |
0.88 (0.51-1.51) |
2.21 (0.89-5.47) |
|
|
|||||
|
CDH1 |
2.13 (0.86-5.22) |
0.83 (0.53-1.30) |
1.41 (0.59-3.39) |
0.91 (0.55-1.50) |
2.63 (1.05-6.60)* |
|
|
|||||
|
DAPK1 |
1.45 (0.43-4.87) |
1.16 (0.60-2.24) |
2.11 (0.64-6.92) |
1.83 (0.84-3.98) |
6.64 (1.85-23.8)* |
|
|
|||||
|
IRX2 |
1.29 (0.54-3.06) |
0.76 (0.48-1.19) |
1.06 (0.45-2.52) |
0.91 (0.55-1.50) |
2.89 (1.17-7.13)* |
|
|
|||||
|
TIMP3 |
1.09 (0.46-2.60) |
1.09 (0.70-1.71) |
1.09 (0.46-2.60) |
1.27 (0.76-2.11) |
2.51 (1.01-6.21)* |
|
|
|||||
|
PAX6 |
1.04 (0.37-2.88) |
1.19 (0.70-2.03) |
0.78 (0.27-2.25) |
0.93 (0.51-1.69) |
1.04 (0.37-2.88) |
|
|
|||||
|
Genes |
Tumor size2 |
Lymph node metastasis |
Pleural indentation |
Invasion or Adhesion |
Histologic stage3 |
|
|
|||||
|
CALCA |
1.01 (0.55-1.88) |
1.74 (0.62-4.91) |
1.18 (0.41-3.41) |
2.44 (0.88-6.79) |
2.13 (1.01-4.47)* |
|
|
|||||
|
CDH1 |
1.20 (0.67-2.13) |
1.02 (0.41-2.51) |
1.79 (0.67-4.76) |
0.96 (0.41-2.27) |
1.11 (0.62-2.02) |
|
|
|||||
|
DAPK1 |
1.81 (0.72-4.54) |
5.17 (0.64-41.95) |
1.63 (0.33-8.02) |
1.70 (0.43-6.67) |
1.24 (0.50-3.08) |
|
|
|||||
|
IRX2 |
1.57 (0.88-2.83) |
1.17 (0.47-2.88) |
1.37 (0.52-3.63) |
0.86 (0.36-2.01) |
1.14 (0.63-2.07) |
|
|
|||||
|
TIMP3 |
1.67 (0.92-3.01) |
2.05 (0.82-5.10) |
1.16 (0.44-3.05) |
0.69 (0.29-1.66) |
1.88 (1.01-3.49)* |
|
|
|||||
|
PAX6 |
0.78 (0.40-1.54) |
0.74 (0.26-2.09) |
2.04 (0.54-7.69) |
1.84 (0.61-5.56) |
1.76 (0.79-3.93) |
|
|
|||||
|
† OR: odds ratio with 95% confidence interval. 1 Pack-years (0; > 0 and < 40; ≥ 40). 2 Tumor size (> 1 and ≤3; > 3 and ≤5; > 5). 3 Histologic stage (I; II; III). * Significant at P < 0.05. |
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|
Ji et al. Diagnostic Pathology 2011 6:48 doi:10.1186/1746-1596-6-48 |
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