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The CEACAM1 expression is decreased in the liver of severely obese patients with or without diabetes

Wonae Lee

Author affiliations

Department of Pathology, Dankook University College of Medicine, Cheonan, Korea

Citation and License

Diagnostic Pathology 2011, 6:40  doi:10.1186/1746-1596-6-40

Published: 11 May 2011



Type 2 diabetes is mainly caused by insulin resistance. The carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) is an important candidate for causing insulin resistance.


The CEACAM1 expression was evaluated immunohistochemically in the liver tissues of 99 severely obese or non-obese subjects with or without diabetes. The CEACAM1 expression was classified into two categories: a normal expression or a decreased expression.


The CEACAM1 expression was markedly decreased in the hepatocytes with macrovesicular steatosis. A decreased CEACAM1 expression was noted in 29 (29%) of 99 cases. The incidence of a decreased CEACAM1 expression was significantly higher in high grade fatty liver as well as severe obesity with or without diabetes (p < 0.05). The incidence of a decreased CEACAM1 expression was not different between the diabetic and non-diabetic groups.


This data supports that a decreased CEACAM1 expression is related to obesity and a fatty liver.