Lymphoepithelioma-like carcinoma of the vulva, an underrecognized entity? Case report with a single inguinal micrometastasis detected by sentinel node technique
1 Dept. of Pathology, Krankenhaus Barmherzige Schwestern, Linz, Austria
2 Dept. of Gynecology, Krankenhaus Barmherzige Schwestern, Linz, Austria
3 Laboratory of Molecular Biology and Tumorcytogenetics, I. Internal dept., Krankenhaus Barmherzige Schwestern, Linz, Austria
Diagnostic Pathology 2011, 6:4 doi:10.1186/1746-1596-6-4Published: 10 January 2011
This report describes an unusual EBV-negative lymphoepithelioma-like carcinoma of the vulva in a 73-year-old patient. The lesion was localised at the right minor labium and was resected by partial vulvectomy. A synchronous sentinel lymph node biopsy revealed a single micrometastasis in the right inguinal region, which prompted local radiotherapy. Follow-up nine months later showed only slight vulvar atrophy, without signs of local recurrence or distant metastases.
Although lymphoepithelioma-like carcinomas of the skin and the female genital tract are presumed to have a better prognosis than their counterparts in the upper aerodigestive tract, possibly due to earlier detection and therapy, this case documents their potential for early metastasis.