Table 4

Tumor differentiation and budding, and expression of CD44 extracellular domain, MMP-7, laminin-5γ2, and sialyl LeX in invasive fronts

n

Tumor budding (/cm)

CD44

MMP-7

Laminin-5γ2

Sialyl LeX


Sporadic cancer

Well differentiated

30

206.7 ± 293.9

5.5 ± 2.8*

4.2 ± 3.4

5.2 ± 2.7

3.2 ± 3.3

Moderetely differentiated

37

264.0 ± 240.6

5.1 ± 2.6

4.4 ± 3.4

5.7 ± 2.7

4.2 ± 3.1

Poorly differentiated

8

395.8 ± 280.5

6.6 ± 2.6**

2.6 ± 2.9

4.6 ± 3.5

1.1 ± 0.8

UC-cancer

Well differentiated

6

146.2 ± 239.4

2.2 ± 1.5*

3.8 ± 2.8

4.0 ± 2.6

1.3 ± 2.3

Moderately differentiated

4

157.0 ± 178.7

2.8 ± 1.5

4.7 ± 1.5

5.0 ± 1.2

1.0 ± 0.0

Poorly differentiated

5

145.8 ± 213.4

1.2 ± 1.6**

1.0 ± 1.0

1.8 ± 2.0

1.4 ± 1.5


MMP - matrix metalloproteinase; n - number of cases; LeX - Lewis X; UC - ulcerative colitis.

* P = 0.010

** P < 0.001

Mikami et al. Diagnostic Pathology 2011 6:30   doi:10.1186/1746-1596-6-30

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