Representative expression of matrix metalloproteinase-7 (MMP-7), laminin-5γ2, and sialyl Lewis X (LeX) in an ulcerative colitis (UC)-associated colon carcinoma case (A-C) and a sporadic colon carcinoma case (D-F). While MMP-7 expression is low in the UC-associated carcinoma with limited tumor budding (A), strong expression is seen in a sporadic carcinoma with frequent tumor budding (D). Laminin-5γ2 expression observed in invasive fronts of both UC-associated (B) and sporadic (E) cases, especially at tumor budding foci. Note that while no expression of LeX is apparent in a UC-associated case (C), strong immunoreactivity is evident in the sporadic lesion (F).
Mikami et al. Diagnostic Pathology 2011 6:30 doi:10.1186/1746-1596-6-30