Representative photographs of CD44 extracellular domain, Zo-1, and occludin expression. CD44 extracellular domain is not expressed at the cell membrane of the invasive part of ulcerative colitis (UC)-associated well differentiated carcinoma (A) and a poorly differentiated carcinoma (B). On the other hand, in a case of sporadic well differentiated (C) and a case of sporadic poorly differentiated adenocarcinoma (D), membranous expression of CD44 extracellular domain is observed. Linear expression of Zo-1 (E) and occludin (F) is seen at the luminal surface in a case of UC-associated well differentiated carcinoma. However, in a UC-associated poorly differentiated case, dot-like expression of both Zo-1 (G) and occludin (H) is observed on the cell surface.
Mikami et al. Diagnostic Pathology 2011 6:30 doi:10.1186/1746-1596-6-30