Figure 3.

A-E Immunohistochemical staining of SP-A (A, B), CK (C), KL-6 (D), and EMA (E) in lung tissue obtained from UIP patients. Figs. B-E show tissue obtained from the same patient. While many regenerative/hyperplastic alveolar epithelial cells expressed SP-A in a lung tissue from a UIP patient (A), SP-A expression is observed in only a few regenerative/hyperplastic alveolar epithelial cells and in intraalveolar macrophages in lung tissue from another patient (B). Almost all regenerative/hyperplastic alveolar epithelial cells expressed CK, KL-6, and EMA (C,D,E). (Immunoperoxidase and hematoxylin, × 140).