Reticulin and CD34 stains for the liver core biopsy of a 71-year old patient with well differentiated hepatocellular carcinoma (HCC). (A) Abnormal reticulin staining pattern in one area of HCC, showing widened trabeculae with greater than three cell layers in thickness. (B) Unusual reticulin staining pattern in another area of HCC. The tumor shows well preserved reticulin network, which surrounds individual tumor cells in a monolayered trabecular pattern. (C) CD34 stain in HCC (same area as A). Diffuse positive sinusoidal CD34 stain is present. (D) CD34 stain in HCC (same area as B). Diffuse positive sinusoidal CD34 stain is present.
Hong et al. Diagnostic Pathology 2011 6:15 doi:10.1186/1746-1596-6-15