Reticulin and CD34 stains for the liver core biopsy of a 55-year old patient with history of cirrhosis and well differentiated hepatocellular carcinoma (HCC). (A) Reticulin stain in the area of cirrhosis. Well preserved reticulin network is present. The trabecular plates are thin, and less than two cell in thickness. (B) Reticulin stain in the area of HCC. The tumor shows well preserved reticulin network, which surrounds individual tumor cells in a monolayered trabecular pattern. (C) CD34 stain in the area of cirrhosis (same area as A). Only rare positive stain is present in the peripheral area of the regenerative nodules. (D) CD34 stain in the area of HCC (same area as B). Diffuse positive sinusoidal CD34 stain is present in the tumor.
Hong et al. Diagnostic Pathology 2011 6:15 doi:10.1186/1746-1596-6-15