Research
Diagnostic significance of CK19, TG, Ki67 and galectin-3 expression for papillary thyroid carcinoma in the northeastern region of China
1 Department of general surgery, The First affiliated hospital, China Medical University (Nanjing North Street), Shenyang (110001), China
2 Department of Magnetic Resonance Imaging, No. 404 Hospital of People's Liberation Army (Baoquan Road), Weihai (264200), China
3 Department of genetics, China Medical University (North 2. Road), Shenyang (110001), China
4 Department of rehabilitation, The First affiliated hospital, China Medical University (Nanjing North Street), Shenyang (110001), China
5 Department of pathology, The First affiliated hospital, China Medical University (Nanjing North Street), Shenyang (110001), China. Department of pathology, China Medical University (North 2. Road), Shenyang (110001), China
6 Department of digestive medicine, The First affiliated hospital, China Medical University (Nanjing North Street), Shenyang (110001), China
Diagnostic Pathology 2011, 6:126 doi:10.1186/1746-1596-6-126
Published: 21 December 2011Abstract
Background
To evaluate the expression and differential diagnostic significance of CK19, TG, Ki67 and galectin-3 in papillary thyroid carcinoma (PTC) (metastatic and non metastatic), follicular adenoma and nodular goiter in patients from the northeastern part of China.
Methods
441 PTC specimens and 151 other benign thyroid specimens (97 cases of nodular goiter, 54 cases of nonmalignant follicular adenoma) were collected. Immunohistochemistry for CK19, TG, Ki67 and galectin-3 was performed.
Results
CK19, TG, Ki67 and galectin-3 expression was 96.37% (425/441), 82.77% (365/441), and 40.59% (179/441), 96.82% (427/441), respectively, for the PTC group and the expression of these markers in the benign thyroid lesions group was 25.83% (39/151), 79.47% (120/151), and 37.09% (56/151), 50.99% (77/151), respectively. The expression of CK19 and galectin-3 in PTC was much higher than that in the nonmalignant group (p < 0.05). However, the expression of TG, Ki67 did not differ among these two groups (p > 0.05). The diagnostic efficiency of CK19 and galectin-3 for PTC was 96.37% (537/592) and 84.63% (501/592). CK19 and galectin-3 expression rate in PTC was higher than that in benign disease cases.
Conclusions
The diagnostic efficiency of CK19 for PTC was slightly better than galectin-3. The utilization of these markers combined with morphologic evaluation may be helpful in the differential diagnosis of papillary thyroid carcinoma in the northeastern region of China.
