Table 1 |
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Frequencies of methylation of analyzed genes in PB and breast tumors. |
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|
GENE |
Chromosomal region targeted by assay * |
Number of paired samples used/excluded** |
Methylated in both blood and tumor Sample no. (%) |
Methylated only tumor*** |
Methylated only PBL Sample no. (%) |
|
|
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|
BRCA1 |
chr17:41, 277, 382-41, 277, 409 |
75/6 |
3 (4.3%) |
23% |
3 (4.3%) |
|
|
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|
APC |
chr5:112, 073, 470-112, 073, 516 |
75/3 |
3 (4.1%) |
83% |
2 (2.7%) |
|
|
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|
RASSF1A |
chr3:50, 377, 755-50, 378, 089 |
75/2 |
0% |
97% |
0 |
|
|
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|
* UCSC Genome Browser on Human Feb. 2009 (GRCh37/hg19) Assembly ** Samples excluded due to failure of PCR amplification *** Out of all tumor samples used |
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|
Wojdacz et al. Diagnostic Pathology 2011 6:116 doi:10.1186/1746-1596-6-116 |
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