Table 1

Tumor grade, size and stage in compare to immunohistochemicals markers (mEGFR, nEGFR, Cyclin D1) and EGFR FISH in CRC

Grade

pT

Tumor stage

Parameters

Total

low

high

p-value

1

2

3

4

p-value

1

2

3

4

p-value


mEGFR

0.042

0.506

0.769

neg./week

49

47

2

2

35

12

0

22

4

23

0

moderate

64

54

10

0

39

23

2

22

9

33

0

strong

22

20

2

0

12

9

1

7

4

10

1

nEGFR

0.427

0.452

0.943

neg./week

9

9

0

0

6

3

0

4

2

3

0

moderate

49

44

5

2

25

20

2

15

11

22

1

strong

77

68

9

0

55

21

1

32

4

41

0

Cyclin D1

0.363

0.335

0.588

neg./week

8

8

0

0

7

1

0

4

1

3

0

moderate

51

46

5

2

24

22

3

14

11

25

1

strong

76

67

9

0

55

21

0

33

5

38

0

EGFR FISH

0.486

0.713

0.178

≤ 2.0 - 2.49

117

106

12

2

78

34

3

47

14

56

0

2.5 - 2.93

10

9

0

0

5

5

0

2

2

5

1

≥ 2.94

8

6

2

0

3

5

0

2

1

5

0


Total

135

121

14

2

86

44

3

51

17

66

1


CRC, colorectal carcinoma

mEGFR, membrane EGFR

nEGFR, nuclear EGFR

test - Spearman rank correlation coefficient

Dekanić et al. Diagnostic Pathology 2011 6:108   doi:10.1186/1746-1596-6-108

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