Table 1 |
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|
Tumor grade, size and stage in compare to immunohistochemicals markers (mEGFR, nEGFR, Cyclin D1) and EGFR FISH in CRC |
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|
Grade |
pT |
Tumor stage |
||||||||||||
|
Parameters |
Total |
low |
high |
p-value |
1 |
2 |
3 |
4 |
p-value |
1 |
2 |
3 |
4 |
p-value |
|
|
||||||||||||||
|
mEGFR |
0.042 |
0.506 |
0.769 |
|||||||||||
|
neg./week |
49 |
47 |
2 |
2 |
35 |
12 |
0 |
22 |
4 |
23 |
0 |
|||
|
moderate |
64 |
54 |
10 |
0 |
39 |
23 |
2 |
22 |
9 |
33 |
0 |
|||
|
strong |
22 |
20 |
2 |
0 |
12 |
9 |
1 |
7 |
4 |
10 |
1 |
|||
|
nEGFR |
0.427 |
0.452 |
0.943 |
|||||||||||
|
neg./week |
9 |
9 |
0 |
0 |
6 |
3 |
0 |
4 |
2 |
3 |
0 |
|||
|
moderate |
49 |
44 |
5 |
2 |
25 |
20 |
2 |
15 |
11 |
22 |
1 |
|||
|
strong |
77 |
68 |
9 |
0 |
55 |
21 |
1 |
32 |
4 |
41 |
0 |
|||
|
Cyclin D1 |
0.363 |
0.335 |
0.588 |
|||||||||||
|
neg./week |
8 |
8 |
0 |
0 |
7 |
1 |
0 |
4 |
1 |
3 |
0 |
|||
|
moderate |
51 |
46 |
5 |
2 |
24 |
22 |
3 |
14 |
11 |
25 |
1 |
|||
|
strong |
76 |
67 |
9 |
0 |
55 |
21 |
0 |
33 |
5 |
38 |
0 |
|||
|
EGFR FISH |
0.486 |
0.713 |
0.178 |
|||||||||||
|
≤ 2.0 - 2.49 |
117 |
106 |
12 |
2 |
78 |
34 |
3 |
47 |
14 |
56 |
0 |
|||
|
2.5 - 2.93 |
10 |
9 |
0 |
0 |
5 |
5 |
0 |
2 |
2 |
5 |
1 |
|||
|
≥ 2.94 |
8 |
6 |
2 |
0 |
3 |
5 |
0 |
2 |
1 |
5 |
0 |
|||
|
|
||||||||||||||
|
Total |
135 |
121 |
14 |
2 |
86 |
44 |
3 |
51 |
17 |
66 |
1 |
|||
|
|
||||||||||||||
|
CRC, colorectal carcinoma mEGFR, membrane EGFR nEGFR, nuclear EGFR test - Spearman rank correlation coefficient |
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|
Dekanić et al. Diagnostic Pathology 2011 6:108 doi:10.1186/1746-1596-6-108 |
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