Table 2

MUC gene expression and logistic regression analysis of associations between MUC family genes and clinical characteristics

MUC1 (n = 53)

MUC2 (n = 50)

MUC5AC (n = 51)

MUC6 (n = 48)


Variable

No. (%)


Gene Expression

Positive

38 (71.7)

10 (20.0)

22 (43.1)

13 (27.1)

Negative

15 (28.3)

40 (80.0)

29 (56.9)

35 (72.9)


OR (95% C.I.)


Age

1.02 (0.97, 1.07)

1.01 (0.95, 1.07)

1.07 (1.11, 1.14)*

1.04 (0.97, 1.10)

Gender

Female

1.00

1.00

1.00

1.00

Male

2.45 (0.73, 8.42)

2.96 (0.56, 15.73)

0.88 (0.28, 2.74)

2.22 (0.52, 9.54)

Tumor size

0.90 (0.50, 1.65)

0.72 (0.32, 1.58)

1.60 (0.86, 2.97)

0.50 (0.22, 1.11)

Location

Lower end of the common bile duct

1.00

1.00

1.00

Ampullary duodenum

0.22 (0.02, 1.93)

-

1.08 (0.13, 8.80)

-

Papillary duodenum

0.35 (0.10, 1.31)

1.25 (0.31, 5.09)

0.58 (0.18, 1.91)

1.50 (0.41, 5.51)

Tumor differentiation

No & Low

1.00

1.00

1.00

1.00

Middle & High

4.71 (1.26, 17.66)*

0.91 (0.22, 3.62)

1.55 (0.51, 4.74)

0.47 (0.13, 1.72)

Tumor classification

T0 & T1 & T2

1.00

1.00

1.00

1.00

T3 & T4

1.50 (0.45, 5.05)

0.43 (0.10, 1.90)

2.05 (0.66, 6.31)

1.56 (0.43, 5.59)

Node classification

N0

1.00

1.00

1.00

1.00

N1

1.09 (0.32, 3.69)

1.00 (0.23, 4.11)

1.90 (0.61, 5.90)

0.36 (0.08, 1.52)

Distant metastasis

M0

1.00

1.00

1.00

1.00

M1

0.38 (0.02, 6.47)

-

1.33 (0.80, 22.57)

-

TNM stage

0 & I

1.00

1.00

1.00

1.00

II & III & IV

1.28 (0.37, 4.39)

0.54 (0.13, 2.18)

1.88 (0.57, 6.21)

0.69 (0.19, 2.50)

Vessel invasion,

No

1.00

1.00

1.00

1.00

Yes

1.63 (0.38, 6.92)

1.13 (0.25, 5.17)

0.14 (0.03, 0.72)*

0.46 (0.09,

Nerve invasion

No

1.00

1.00

1.00

1.00

Yes

1.63 (0.38, 6.92)

1.29 (0.68, 5.94)

3.32 (0.92, 12.01)

0.36, 6.19)


* indicates statistical significance where P < 0.05.

Wang et al. Diagnostic Pathology 2011 6:102   doi:10.1186/1746-1596-6-102

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