Figure 1.

Expression of MK1 and RegIV in the benign and malignant lesions of gallbladder. EnVision immunohistochemistry, original magnification x200. MK1 and RegIV positive reaction was mainly localized in the cell membrance and/or cytoplasm. A, MK1 positive expression in peri-tumor tissue with moderate atypical hyperplasia. B, MK1 positive expression in highly differentiated gall bladder adenocarcinoma. C, RegIV positive expression in polyp with severe atypical hyperplasia. D, RegIV positive expression in moderately differentiated gall bladder adenocarcinoma.