Table 6

Comparison of sensitivity, specificity, PPV and NPV of combined markers expression in Benign vs. Malignant Thyroid Lesions

MARKER

Negative

Positive

Total

GAL-3 + HBME-1

Benign

134

62

196

Sensitivity

0.861

Malignant

15

93

108

Specificity

0.684

Total

149

155

304

PPV

0.600

NPV

0.899

GAL-3 + CK-19

Benign

138

58

196

Sensitivity

0.852

Malignant

16

92

108

Specificity

0.704

Total

154

150

304

PPV

0.613

NPV

0.896

HBME-1 + CK-19

Benign

130

66

196

Sensitivity

0.861

Malignant

15

93

108

Specificity

0.663

Total

145

159

304

PPV

0.585

NPV

0.897

GAL-3+HBME+CK-19

Benign

201

93

294

Sensitivity

0.858

Malignant

23

139

162

Specificity

0.684

Total

224

232

456

PPV

0.599

NPV

0.897

Gal-3, galectin-3; Ret, Ret oncoprotein; CK19, cytokeratin 19; PPV, positive predictive value; NPV, negative predictive value.

Saleh et al. Diagnostic Pathology 2010 5:9   doi:10.1186/1746-1596-5-9