Table 4

Sensitivity, Specificity, Positive (PPV) and Negative (NPV) Predictive Values of the different immunomarkers (%)

Stains vs. Case

N

Overall

Agreement, %

(95% CI)

Sensitivity, % (95% CI)

Specificity, % (95% CI)

PPV

NPV


EGFR

60

65.0 (52.4, 75.8)

100.0 (89.9, 100.0)

19.2 (8.5, 37.9)

61.8

100.0


OSCAR

60

88.3 (77.8, 94.2)

85.3 (69.9, 93.6)

92.3 (75.9, 97.9)

93.6

82.8


P63

60

81.7 (70.1, 89.4)

67.6 (50.8, 80.9)

100.0 (87.1, 100.0)

100.0

70.3


SNAIL

60

58.3 (45.7, 71.8)

100.0 (89.9, 100.0)

3.8 (0.7, 18.9)

57.6

100.0


WSKER

60

86.7 (75.8, 93.1)

76.5 (60.0, 87.6)

100.0 (87.1, 100.0)

100.0

76.5


OSCAR & P63 & WSKER

60

90.0 (79.9, 95.3)

88.2 (73.4, 95.3)

92.3 (75.9. 97.9)

93.8

85.7


OSCAR & WSKER

60

88.3 (77.8, 94.2)

85.3 (69.9, 93.5)

92.3 (75.9, 97.9)

93.6

82.8


OSCAR & P63

60

90.0 (79.9, 95.3)

88.2 (73.4, 95.3)

92.3 (75.9. 97.9)

93.8

85.7


P63 & WSKER

60

90.0 (79.9, 95.3)

82.4 (66.5, 91.7)

100.0 (87.1, 100.0)

100.0

81.2


EGFR = epidermal growth factor receptor; WS-KER = wide spectrum keratin

Nassar et al. Diagnostic Pathology 2010 5:76   doi:10.1186/1746-1596-5-76

Open Data