Table 4 |
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|
Sensitivity, Specificity, Positive (PPV) and Negative (NPV) Predictive Values of the different immunomarkers (%) |
||||||
|
Stains vs. Case |
N |
Overall Agreement, % (95% CI) |
Sensitivity, % (95% CI) |
Specificity, % (95% CI) |
PPV |
NPV |
|
|
||||||
|
EGFR |
60 |
65.0 (52.4, 75.8) |
100.0 (89.9, 100.0) |
19.2 (8.5, 37.9) |
61.8 |
100.0 |
|
|
||||||
|
OSCAR |
60 |
88.3 (77.8, 94.2) |
85.3 (69.9, 93.6) |
92.3 (75.9, 97.9) |
93.6 |
82.8 |
|
|
||||||
|
P63 |
60 |
81.7 (70.1, 89.4) |
67.6 (50.8, 80.9) |
100.0 (87.1, 100.0) |
100.0 |
70.3 |
|
|
||||||
|
SNAIL |
60 |
58.3 (45.7, 71.8) |
100.0 (89.9, 100.0) |
3.8 (0.7, 18.9) |
57.6 |
100.0 |
|
|
||||||
|
WSKER |
60 |
86.7 (75.8, 93.1) |
76.5 (60.0, 87.6) |
100.0 (87.1, 100.0) |
100.0 |
76.5 |
|
|
||||||
|
OSCAR & P63 & WSKER |
60 |
90.0 (79.9, 95.3) |
88.2 (73.4, 95.3) |
92.3 (75.9. 97.9) |
93.8 |
85.7 |
|
|
||||||
|
OSCAR & WSKER |
60 |
88.3 (77.8, 94.2) |
85.3 (69.9, 93.5) |
92.3 (75.9, 97.9) |
93.6 |
82.8 |
|
|
||||||
|
OSCAR & P63 |
60 |
90.0 (79.9, 95.3) |
88.2 (73.4, 95.3) |
92.3 (75.9. 97.9) |
93.8 |
85.7 |
|
|
||||||
|
P63 & WSKER |
60 |
90.0 (79.9, 95.3) |
82.4 (66.5, 91.7) |
100.0 (87.1, 100.0) |
100.0 |
81.2 |
|
|
||||||
|
EGFR = epidermal growth factor receptor; WS-KER = wide spectrum keratin |
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|
Nassar et al. Diagnostic Pathology 2010 5:76 doi:10.1186/1746-1596-5-76 |
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