Immunohistochemical staining for GADD45β A) Enchondroma, B) Grade I Chondrosarcoma, C) Grade II Chondrosarcoma, D) Grade III Chondrosarcoma. Chondrocytes which have plump nuclei and are surrounded by cartilage matrix, are positive for GADD45β. In contrast, most of the atypical and immature cells in grade II or III chondrosarcoma are negative.
Over 70% of the cells in enchondromas expressed GADD45β. In chondrosarcomas, the rate of GADD45β positive cells was inversely proportional to its grade. There were statistically significant differences among three groups except grade III chondrosarcoma. (*: P < 0.01)
Zenmyo et al. Diagnostic Pathology 2010 5:69 doi:10.1186/1746-1596-5-69