Table 4 |
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|
Previous Reports of Immunohistochemically Detectable PSA Expression in Benign and Malignant Breast Lesions |
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|
Author |
Number of Cases |
Antibody, Clone |
PSA Positive |
Comments |
|
|
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|
Carder et al. 2005 [2] |
11 MBC |
Dako, ELY, Cambridgeshire, UK |
1/11 (9%) |
Focal intense staining All cases PSAP negative (Dako) |
|
|
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|
Cheng et al. 2006 [3] |
14 MBC |
Dako, Glostrup, Denmark |
0/14 |
All cases PSAP negative |
|
|
||||
|
Ilvan et al. 2004 [10] |
109 FBC |
Dako USA, monoclonal, prediluted |
11/109 (10.1%) |
All PSA positive cases ER+ PR+ |
|
|
||||
|
Miller et al. 2001 [11] |
75 (74 FBC, 1 MBC) |
Dako M0750 1:320 |
7/75 (9%) |
5/7 showed weak, focal positivity; MBC negative |
|
|
||||
|
Kidwai et al. 2003 [12] |
26 MBC |
Dako polyclonal 1:1800 |
6/26 (23%) |
5 focally positive 1 diffuse All PSAP negative |
|
|
||||
|
Narita et al. 2006 [13] |
156 FBC |
Dako polyclonal, ready to use |
61/156 (39.1%) |
Positive correlation with AR expression |
|
|
||||
|
Hall et al. 1998 [14] |
72 cases |
Dako, Carpinteria, CA |
44/72 (61%) |
|
|
|
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|
Alanen et al. 1999 [15] |
171 cases |
Dakopatts, Glostrup, Denmark, polyclonal 1:1000 |
54/171 (31.6%) |
|
|
|
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|
Gatalica et al. 1999 [19] |
18 gynecomastia, 8 MBC |
Rabbit polyclonal, Ventana Medical Systems, Tucson AZ |
5/18 cases of gynecomastia (27.8%) 0/8 MBC |
Focal strong polyclonal PSA; 4/5 cases tested with monoclonal PSA and were negative All cases PSAP (Ventana PASE/4LT) negative |
|
|
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|
Quraishi et al. 2007 [20] |
30 (8 DCIS, 19 infiltrating ductal carcinoma, 3 metastatic breast carcinoma) |
Polyclonal rabbit |
0/30 |
|
|
|
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|
Gupta 1999 [21] |
2 MBC |
Not reported |
2/2 (100%) |
Cell blocks positive; trace PSA positivity in resection specimens |
|
|
||||
|
Tanaka et al. 2002 [22] |
78 FBC |
Dako A/S Glostrup, Denmark, polyclonal 1:100 |
29/78 (32.7%) |
6 cases strongly positive |
|
|
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|
This article |
54 FBC 30 MBC 5 gynecomastia |
Dako polyclonal 1:10,000 |
2/54 FBC 1/30 MBC 0/5 gynecomastia |
All cases PSAP negative |
|
|
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|
MBC - male breast carcinoma; FBC - female breast carcinoma; PSA - prostate specific antigen; PSAP - prostate specific acid phosphatase; AR - androgen receptor; ER - estrogen receptor; PR - progesterone receptor. |
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|
Kraus et al. Diagnostic Pathology 2010 5:63 doi:10.1186/1746-1596-5-63 |
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