Intracellular and extracellular rhomboid shaped crystalline inclusions in a case of IgG lambda restricted plasma cell myeloma: a case report and review of the literature

doi:10.1186/1746-1596-5-6

Diagnostic Pathology

Volume 5

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Case Report

Intracellular and extracellular rhomboid shaped crystalline inclusions in a case of IgG lambda restricted plasma cell myeloma: a case report and review of the literature

Andres Matoso¹^,3 , Tina Rizack²^,3 and Diana O Treaba¹^,3

¹Department of Pathology and Laboratory Medicine, Rhode Island Hospital, Providence, RI, USA

²Department of Medicine Division of Hematology and Oncology, Rhode Island Hospital, Providence, RI, USA

³Alpert Medical School of Brown University, Providence, RI, USA

author email corresponding author email

Diagnostic Pathology 2010, 5:6doi:10.1186/1746-1596-5-6


Published:	21 January 2010

Abstract

The presence of crystalline inclusions in plasma cell myeloma is a rare phenomenon and cases have been reported with rod, needle, and rectangular shaped crystals. Here, we present a case of IgG lambda restricted plasma cell myeloma with rhomboid shaped intracellular crystalline inclusions and extracellular crystal depositions in the bone marrow. Since rhomboid crystal depositions can be seen in other clinical conditions such as pseudogout, this case invites consideration of plasma cell myeloma in the differential diagnosis of patients with rhomboid crystalline deposition in the bone marrow and in sites/organs other than the bone marrow.