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Open Access Case Report

Low-grade oligodendroglioma of the pineal gland: a case report and review of the literature

Georgia Levidou1*, Penelope Korkolopoulou1, George Agrogiannis1, Nikolaos Paidakakos2, Dimos Bouramas2 and Efstratios Patsouris1

Author affiliations

1 National and Kapodistrian University of Athens, Department of Pathology, Athens, 11527, Greece

2 Department of Neurosurgery, Athens Naval Hospital, Athens 11521, Greece

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Citation and License

Diagnostic Pathology 2010, 5:59  doi:10.1186/1746-1596-5-59

Published: 17 September 2010

Abstract

Background

Gliomas are a very rare subtype of pineal region tumours, whereas oligodendrogliomas of the pineal region are exceedingly rare, since there have been only 3 cases of anaplastic oligodedrogliomas reported this far.

Methods-Results

We present a case of a low-grade oligodendroglioma arising in the pineal gland of a 37 year-old woman. The patient presented with diplopia associated with a cystic pineal region mass demonstrated on MRI. Total resection was performed and histological examination showed that the cystic wall consisted of tumour cells with a central nucleus a perinuclear halo and minimal pleomorphism. Immnunohistochemical analysis showed that these cells were diffusely positive for CD57, and negative for GFAP, CD10, CD99, cytokeratins, neurofilaments and synaptophysin. FISH analysis was performed in a small number of neoplastic cells, which were not exhausted after immunohistochemistry and did not reveal deletion of 1p and 19q chromosome arms. However, the diagnosis of a low grade oligodendroglioma of the pineal gland was assigned.

Conclusion

Although the spectrum of tumours arising in the pineal gland is broad, the reports of oligodendrogliomas confined to this location are exceedingly rare, and to the best of our knowledge there is no report of a low-grade oligodendroglioma. However, they should be added in the long list of tumours arising in the pineal gland.