Down-regulation of HDGF reduced cell migration and invasion. The migrating (A and B) and invading (C and D) capabilities of parental HepG2 cells and their stable derivatives, shCtrl and shHDGF, were examined by transwell and boyden chamber assay. A and C. Migrated or invaded cells were photographed under the microscope (200×). B and D. Quantifications of migration and invasion were presented as mean ± SD for three independent experiments. *P < 0.05, as compared to parental HepG2 cells and shCtrl cells.
Zhou et al. Diagnostic Pathology 2010 5:58 doi:10.1186/1746-1596-5-58