Figure 3.

Expression of phenotypic markers of OGCs. Phenotypes of OGCs in the breast (center panels) were compared those of osteoclastic cells in the bone (far left) and foreign body giant cells (far right). OGCs in the breast displayed both osteoclastic and histiocytic characteristics but lacked antigen presentation abilities. A-D: CD68, a phenotypic marker for histiocytes. E-H: MMP9, a broad marker for macrophage-osteoclast lineage cells. I-L: TRAP. M-P: Cathepsin K. Q-T: HLA-DR.