Table 1

Scoring systems for HER2

HER2 IHC Scoring


Score

Pre-ASCO/CAP Scoring

Interpretation/Staining pattern

ASCO/CAP Scoring

Interpretation/Staining pattern

0

Negative/No staining

Staining in < 10% of tumor cells

Negative/No staining

Staining in <10% of tumor cells

1+

Negative/Faint/barely perceptible

incomplete membrane staining

in >10% of tumor cells

Negative/Faint/barely perceptible

incomplete membrane staining

in >10% of tumor cells

2+

Weakly positive/Weak to moderate

complete membrane staining

in >10% of tumor cells

Equivocal/Weak to moderate

complete membrane staining

in >10% of tumor cells

3+

Strongly positive/Strong complete

membrane staining

in >10% of tumor cells

Positive/Strong complete

membrane staining

in >30% of tumor cells

HER2 FISH Scoring


Pre-ASCO/CAP Scoring

Interpretation/Ratio (HER2/CEP17)

ASCO/CAP Scoring

Interpretation/Ratio (HER2/CEP17)

Negative/<2.0

Negative/< 1.8

Equivocal/1.8-2.2

Positive/>= 2.0

Positive/> 2.2


HER2 human epidermal growth factor receptor 2; IHC immunohistochemistry; FISH fluorescence in situ hybridization; ASCO American Society of Clinical Oncology; CAP College of American Pathologists; CEP17 chromosome enumeration probe 17 (probe for the centromer of chromosome 17)

Vogel Diagnostic Pathology 2010 5:50   doi:10.1186/1746-1596-5-50

Open Data