Table 3 |
|||||
|
Results of immunohistochemical markers response in neurons |
|||||
|
Acute (A) (≤8 hs) Median Expression |
Non-acute (NA) (≥8 hs ≤48 hs) Median Expression |
Controls (C) Median Expression |
Significance Level |
||
|
|
|||||
|
GFAP |
- |
- |
A vs C |
ns |
|
|
NA vs C |
ns |
||||
|
A vs NA |
ns |
||||
|
|
|||||
|
TNF-α |
- |
+ |
- |
A vs C |
*** |
|
NA vs C |
ns |
||||
|
A vs NA |
*** |
||||
|
|
|||||
|
IL-1β |
+ |
++ |
- |
A vs C |
*** |
|
NA vs C |
*** |
||||
|
A vs NA |
*** |
||||
|
|
|||||
|
IL-6 |
- |
+ |
- |
A vs C |
*** |
|
NA vs C |
ns |
||||
|
A vs NA |
*** |
||||
|
|
|||||
|
MAC387 |
- |
- |
- |
A vs C |
ns |
|
NA vs C |
ns |
||||
|
A vs NA |
ns |
||||
|
|
|||||
|
HSP 27 |
- |
- |
- |
A vs C |
ns |
|
NA vs C |
ns |
||||
|
A vs NA |
ns |
||||
|
|
|||||
|
HSP 70 |
+ |
+++ |
- |
A vs C |
*** |
|
NA vs C |
** |
||||
|
A vs NA |
*** |
||||
|
|
|||||
|
HSP 90 |
+ |
+++ |
- |
A vs C |
*** |
|
NA vs C |
** |
||||
|
A vs NA |
*** |
||||
|
|
|||||
|
COX2 |
+++ |
+ |
- |
A vs C |
*** |
|
NA vs C |
*** |
||||
|
A vs NA |
** |
||||
|
|
|||||
|
ORP-150 |
++ |
+ |
- |
A vs C |
*** |
|
NA vs C |
*** |
||||
|
A vs NA |
** |
||||
|
|
|||||
|
β-APP |
+ |
+++ |
++ |
A vs C |
*** |
|
NA vs C |
** |
||||
|
A vs NA |
** |
||||
|
|
|||||
|
TrypH |
- |
+ |
- |
A vs C |
*** |
|
NA vs C |
ns |
||||
|
A vs NA |
*** |
||||
|
|
|||||
|
GAP-43 |
- |
- |
- |
A vs C |
ns |
|
NA vs C |
ns |
||||
|
A vs NA |
ns |
||||
|
|
|||||
|
Apoptosis (TUNEL) |
+ |
++ |
- |
A vs C |
*** |
|
NA vs C |
** |
||||
|
A vs NA |
*** |
||||
|
|
|||||
|
The reactions were graded as follows: 1. (0): not expressed, 2. (+): isolated and disseminated expression, 3. (++): expression in groups or widespread foci, 4. (+++): widespread expression. NS = p > 0.05, * = p < 0.05, ** = p < 0.01, *** = p < 0.001 |
|||||
|
Riezzo et al. Diagnostic Pathology 2010 5:49 doi:10.1186/1746-1596-5-49 |
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