Table 3

Whole tissue section intra-reader agreement and agreement between the second whole tissue section and TMA

B7-H1

B7-H3

Survivin

Ki-67

CAIX*

IMP3

Kappa

CCC

CCC

CCC

CCC

CCC

Whole section

0.78

0.97

0.71

0.90

0.94

0.96

Cores

1

0.21 (0.00 - 0.65)

0.80 (0.73 - 0.87)

0.35 (0.06 - 0.55)

0.63 (0.44 - 0.82)

0.85 (0.73 - 0.94)

0.73 (0.02 - 0.87)

2

0.21 (0.00 - 0.65)

0.81 (0.74 - 0.87)

0.40 (0.12 - 0.57)

0.72 (0.49 - 0.84)

0.82 (0.73 - 0.92)

0.79 (0.20 - 0.85)

3

0.38 (0.00 - 0.65)

0.83 (0.76 - 0.86)

0.43 (0.24 - 0.62)

0.76 (0.62 - 0.86)

0.80 (0.72 - 0.89)

0.81 (0.49 - 0.85)

4

0.38 (0.00 - 0.65)

0.83 (0.77 - 0.85)

0.44 (0.33 - 0.58)

0.79 (0.64 - 0.85)

0.78 (0.71 - 0.87)

0.82 (0.61 - 0.85)

5

0.52 (0.00 - 0.65)

0.83 (0.80 - 0.85)

0.45 (0.36 - 0.57)

0.81 (0.71 - 0.86)

0.77 (0.72 - 0.84)

0.82 (0.77 - 0.85)

6

0.52 (0.00 - 0.65)

0.84 (0.81 - 0.84)

0.45 (0.37 - 0.57)

0.81 (0.71 - 0.85)

0.76 (0.71 - 0.82)

0.82 (0.77 - 0.85)

7

0.65 (0.00 - 0.65)

0.84 (0.81 - 0.84)

0.46 (0.40 - 0.52)

0.82 (0.73 - 0.85)

0.75 (0.72 - 0.82)

0.82 (0.77 - 0.85)

8

0.65 (0.38 - 0.65)

0.84 (0.83 - 0.84)

0.46 (0.41 - 0.51)

0.82 (0.76 - 0.84)

0.74 (0.72 - 0.81)

0.82 (0.79 - 0.85)

9

0.65 (0.52 - 0.65)

0.84 (0.83 - 0.84)

0.46 (0.43 - 0.48)

0.82 (0.79 - 0.84)

0.73 (0.72 - 0.79)

0.82 (0.80 - 0.84)

10

0.65 (0.65 - 0.65)

0.84 (0.84 - 0.84)

0.46 (0.46 - 0.46)

0.82 (0.82 - 0.82)

0.73 (0.73 - 0.73)

0.82 (0.82 - 0.82)

*CAIX was analyzed using the minimum value across cores. All other biomarkers were analyzed using the maximum value across cores.

The kappa statistic is reported for B7-H1, whereas the concordance correlation coefficient (CCC) is reported for B7-H3, survivin, Ki-67, CAIX, and IMP3; the median (minimum, maximum) statistic from the 500 bootstrap samples is provided.

Eckel-Passow et al. Diagnostic Pathology 2010 5:48   doi:10.1186/1746-1596-5-48