Table 2

Summary of biomarker expression for the second whole tissue section quantification

Distribution of expression values

Biomarker

Quantitation

Method*

0%

(min)

10%

25%

50%

(median)

75%

90%

100%

(max)


B7-H1

%

0

0

0

0

0

0

10

B7-H3

%

0

0

0

0

0

5

100

IMP3

%

0

0

0

0

0

10

80

CAIX

%

0

20

100

100

100

100

100

Survivin

mm2

0.65

1.95

2.61

4.56

12.38

25.41

82.08

Ki-67

mm2

0.65

2.61

12.05

24.76

41.69

68.08

329.64


*The membranous and cytoplasmic staining patterns of B7-H1, B7-H3, IMP3, and CAIX were quantitated as the percentage of positive tumor cells in 5-10% increments, whereas the nuclear staining patterns of survivin and KI-67 were quantitated as the number of positive tumor cells per mm2.

Eckel-Passow et al. Diagnostic Pathology 2010 5:48   doi:10.1186/1746-1596-5-48

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