Table 9

Survival-related single factors, tendencies of correlation

Factor

Relation to survival, clear tendency

Significant (only) in bivariate correlation with survival (two-tailed), level


IHC markers, semiquantitatively, when increasing number of cells with positive IR:


Calretinin, nucleus

-


Calretinin, cytoplasm

-


EMA, cell membrane

-


EMA, cytoplasm

-


Podoplanin, cell membrane

0.001


Mesothelin, cell membrane

if 0-50%: ↓

51-100%: ↑

-


Ber-Ep4, general

if 1-25%: (↓)

-


Histological type


Epithelial

0.05 (non-parametric)


Mixed

0.01 (non-parametric)


Histological markers


a) when increasing:


Degree of cellular atypia

0.001


Spindle cells, semiquantitatively

if 0: ↑; otherwise: ↓

0.001 (non-parametric)


Number of mitoses (10 HPF)

if 0 or 1: ↑; otherwise:↓

0.05 (Spearman's rho)


Number of atypical mitoses (10 HPF)

if 0: ↑; otherwise: ↓

-


Necrosis

0.01


Mucus, cytoplasm, number of cells

if high: (↓)

-


Mucus, extracellular, number of cells

-


Accompanying inflammation, intensity

-


Accompanying inflammation, focality

-


b) if present:


MM spreading, perineural

(↔)

-


MM spreading, intralymphangic

(↔)

-


MM spreading, intralymphangic and venoles

(↓)

-


No/no evident MM spreading

-


Accompanying inflammation, active

(↔)

-


Accompanying inflammation, non-active

-


Localisation of primary tumour


Pleura

-


Peritoneum

0.01 (parametric)

0.05 (non-parametric)


Pleura and peritoneum

(↓)

-


Mediastinum, not specified

(↓)

-


Pericardium

(↓)

-


Scrotum

(↓)

-


Metastasis

0.05 (non-parametric)


yes


no/not known


Sex

-


Female

-


Male

-


Age at time of diagnosis, when increasing:

0.01


In parentheses: very few cases

Survival is given per April 21, 2008.

Sandeck et al. Diagnostic Pathology 2010 5:47   doi:10.1186/1746-1596-5-47

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