Table 6

Sensitivity and specificity, confirmed MM cases

Marker

Sensitivity, MM

Specificity, against carcinoma


Positive MM markers

positive IR, number

positive IR, %

literature data, %

negative IR, number %

negative IR, %

literature data, %


Calretinin, nucleus

49/49

100

821

96.42

5/5

100

851;2


EMA, cell membrane

43/49

87.8

843

3/5

60

563


Podoplanin, cell membrane

44/46

95.6

864

2/3

66.7

1004


Mesothelin, cell membrane

44/48

91.7

1005

4/4

100

615


Thrombomodulin, cell membrane

7/7

100

611

2/5

40

801


HBME-1, cell membrane or cytoplasm

(4+2)/8

75

851

(2-1)/5

20

431


CK5/6

3/3

100

831

3/5

60

851


Negative MM markers

negative IR, number

negative IR, %

positive IR, number

positive IR, %


CEA, monoclonal

49/49

100

811

1/5

20

971


Ber-Ep4

40/49

81.6

801

3/5

60

901


CD15

7/7

100

84.96

1/5

20

816


Sialosyl-TN

6/7

85.7

76.56

1/5

20

816


TTF-1

3/3

100

721

5/5

100

1001


Specificity, own results: against AC and pulmonary pleomorphic carcinoma.

Comparison to some selected data from literature.

1 King et al. 2006, meta-analysis of literature data, MM with epithelioid areas against pulmonary AC [27].

2 Takeshima et al. 2009: sensitivity epithelial/mixed MM 96.4%/90% [1]. Yaziji et al. 2006: sensitivity 95%, specificity against AC 87%, both with 10% positive cutoff [28].

1, 2 Calretinin IR not specified.

3 Wick et al. 1990, related to epithelial MM and pulmonary AC [29].

4 Ordóñez 2005, related to epithelial MM and AC [21].

5 Ordóñez 2003a, related to epithelial MM and pulmonary AC [30].

6 Brockstedt et al. 2000, related to epithelial/mixed MM and AC [31].

Sandeck et al. Diagnostic Pathology 2010 5:47   doi:10.1186/1746-1596-5-47

Open Data