Table 6

Sensitivity and specificity, confirmed MM cases

Marker

Sensitivity, MM

Specificity, against carcinoma

Positive MM markers

positive IR, number

positive IR, %

literature data, %

negative IR, number %

negative IR, %

literature data, %

Calretinin, nucleus

49/49

100

82¹

96.4²

5/5

100

85^1;2

EMA, cell membrane

43/49

87.8

84³

3/5

60

56³

Podoplanin, cell membrane

44/46

95.6

86⁴

2/3

66.7

100⁴

Mesothelin, cell membrane

44/48

91.7

100⁵

4/4

100

61⁵

Thrombomodulin, cell membrane

7/7

100

61¹

2/5

40

80¹

HBME-1, cell membrane or cytoplasm

(4+2)/8

75

85¹

(2-1)/5

20

43¹

CK5/6

3/3

100

83¹

3/5

60

85¹

Negative MM markers

negative IR, number

negative IR, %

positive IR, number

positive IR, %

CEA, monoclonal

49/49

100

81¹

1/5

20

97¹

Ber-Ep4

40/49

81.6

80¹

3/5

60

90¹

CD15

7/7

100

84.9⁶

1/5

20

81⁶

Sialosyl-TN

6/7

85.7

76.5⁶

1/5

20

81⁶

TTF-1

3/3

100

72¹

5/5

100

100¹

Specificity, own results: against AC and pulmonary pleomorphic carcinoma.

Comparison to some selected data from literature.

¹ King et al. 2006, meta-analysis of literature data, MM with epithelioid areas against pulmonary AC [27].

² Takeshima et al. 2009: sensitivity epithelial/mixed MM 96.4%/90% [1]. Yaziji et al. 2006: sensitivity 95%, specificity against AC 87%, both with 10% positive cutoff [28].

^{1, 2} Calretinin IR not specified.

³ Wick et al. 1990, related to epithelial MM and pulmonary AC [29].

⁴ Ordóñez 2005, related to epithelial MM and AC [21].

⁵ Ordóñez 2003a, related to epithelial MM and pulmonary AC [30].

⁶ Brockstedt et al. 2000, related to epithelial/mixed MM and AC [31].

Sandeck et al. Diagnostic Pathology 2010 5:47   doi:10.1186/1746-1596-5-47