Email updates

Keep up to date with the latest news and content from Diagnostic Pathology and BioMed Central.

Open Access Highly Accessed Case Report

Thyroid transcription factor-1 positive primary breast cancer: a case report with review of the literature

Tor A Klingen1*, Ying Chen1, Marian D Gundersen2, Hans Aas3, Bjørn Westre4 and Torill Sauer5

Author affiliations

1 Department of Pathology, Vestfold County Hospital, Halfdan Wilhelmsens Alle' 17, N-3116 Tønsberg, Norway

2 Department of Radiology, Vestfold County Hospital, Halfdan Wilhelmsens Alle' 17, N-3116 Tønsberg, Norway

3 Department of Surgery, Vestfold County Hospital, Halfdan Wilhelmsens Alle' 17, N-3116 Tønsberg, Norway

4 Department of Pathology, Ålesund Hospital, Åsehaugen 5, N-6017 Ålesund, Norway

5 Department of Pathology, Ullevål University Hospital, Kirkeveien 166, N- 0407 Oslo, Norway

For all author emails, please log on.

Citation and License

Diagnostic Pathology 2010, 5:37  doi:10.1186/1746-1596-5-37

Published: 17 June 2010

Abstract

This case describes an infiltrating breast tumour with thyroid transcription factor-1 (TTF-1) positive staining and ductal differentiation in a 72-year-old woman. The presence of ductal carcinoma in situ with positive TTF-1 is a strong indication that this is a primary tumour and not a metastasis from lung.

On PET scan and CT follow up there were no other tumours found in this patient. We are not aware of any previously reported TTF-1 positive primary breast carcinoma with ductal differentiation.