Spectrum of chromosomal abnormalities in renal oncocytomas observed in our study using fluorescent in-situ hybridization panel. In addition to isolated loss of chromosome 1, a wide variety of combined losses was detected. The previously described chromosomal profile (no abnormalities or isolated loss of chromosome 1) could possibly distinguish renal oncocytoma from ChRCC; however, these were seen in only 30% of renal oncocytomas in our study. In contrary, one of the ChRCCs with typical morphology and positivity for Hale's colloidal iron showed no chromosomal abnormalities.
Dvorakova et al. Diagnostic Pathology 2010 5:32 doi:10.1186/1746-1596-5-32