Tissue of Origin Test workflow and results. RNA from frozen tissue is extracted, amplified, and biotin-labeled before hybridization to a Pathchip™ microarray. Gene expression data are then analyzed and a report indicating the studied tissue's molecular similarity to established profiles for 15 tissues of origin is produced.
Monzon et al. Diagnostic Pathology 2010 5:3 doi:10.1186/1746-1596-5-3