Table 2 |
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|
Summary of phenotypical expression analysis by immunohistochemical examination |
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|
Literature summary* |
Present case |
|||||
|
|
||||||
|
Epithelioid cell |
Spindle-Shaped cell |
Ganglion-like cell |
Epithelioid cell |
Spindle-Shaped cell |
Ganglion-like cell |
|
|
CD56 |
NR |
NR |
NR |
+ |
- |
+ |
|
Chromogranin A |
4/4 |
0/2 |
1/2 |
- |
- |
- |
|
Somatostatin |
3/3 |
0/1 |
2/2 |
+ |
- |
+ |
|
Synaptophysin |
4/4 |
1/3 |
3/3 |
+ |
- |
+ |
|
S-100 |
1/2 |
6/6 |
0/2 |
- |
+ |
- |
|
CK |
1/1 |
NR |
NR |
- |
- |
- |
|
NF |
1/2 |
2/3 |
1/2 |
ND |
ND |
ND |
|
NSE |
3/3 |
3/3 |
2/2 |
ND |
ND |
ND |
|
PP |
1/2 |
0/1 |
2/2 |
ND |
ND |
ND |
|
bcl-2 |
NR |
NR |
NR |
- |
- |
- |
|
p53 |
NR |
NR |
NR |
- |
- |
- |
|
|
||||||
|
CK: Cytokeratin, NF: Neurofilament, NSE: Neuron-specific enolase, PP: Pancreatic polypeptide NR: Not reported, ND: Not done in the present case. *: Based on referenced [1,16-19], and [21]. In the present case, three identical components have been clearly identified by phenotypical expression analysis, which corresponds to those previously reported with the exception for chromogranin A. Furthermore, we found lymph node metastasis despite lack of bcl-2 and p53 expression. |
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|
Okubo et al. Diagnostic Pathology 2010 5:27 doi:10.1186/1746-1596-5-27 |
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