Table 2

Summary of phenotypical expression analysis by immunohistochemical examination

Literature summary*

Present case


Epithelioid cell

Spindle-Shaped cell

Ganglion-like cell

Epithelioid cell

Spindle-Shaped cell

Ganglion-like cell

CD56

NR

NR

NR

+

-

+

Chromogranin A

4/4

0/2

1/2

-

-

-

Somatostatin

3/3

0/1

2/2

+

-

+

Synaptophysin

4/4

1/3

3/3

+

-

+

S-100

1/2

6/6

0/2

-

+

-

CK

1/1

NR

NR

-

-

-

NF

1/2

2/3

1/2

ND

ND

ND

NSE

3/3

3/3

2/2

ND

ND

ND

PP

1/2

0/1

2/2

ND

ND

ND

bcl-2

NR

NR

NR

-

-

-

p53

NR

NR

NR

-

-

-


CK: Cytokeratin, NF: Neurofilament, NSE: Neuron-specific enolase, PP: Pancreatic polypeptide

NR: Not reported, ND: Not done in the present case.

*: Based on referenced [1,16-19], and [21].

In the present case, three identical components have been clearly identified by phenotypical expression analysis, which corresponds to those previously reported with the exception for chromogranin A. Furthermore, we found lymph node metastasis despite lack of bcl-2 and p53 expression.

Okubo et al. Diagnostic Pathology 2010 5:27   doi:10.1186/1746-1596-5-27

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