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Malignant peripheral nerve sheath tumor associated with neurofibromatosis type 1, with metastasis to the heart: a case report

Masanori Kitamura1, Naoki Wada2, Shigenori Nagata1, Norishige Iizuka1, Yu-Fen Jin1, Miki Tomoeda1, Michiko Yuki1, Norifumi Naka3, Nobuhito Araki3, Chikao Yutani4 and Yasuhiko Tomita1*

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Author affiliations

1 Department of Pathology, Osaka Medical Center for Cancer and Cardiovascular Diseases, 1-3-3 Nakamichi, Higashinari, Osaka, 537-8511, Japan

2 Department of Pathology, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan

3 Department of Orthopedic surgery, Osaka Medical Center for Cancer and Cardiovascular Diseases, 1-3-3 Nakamichi, Higashinari, Osaka, 537-8511, Japan

4 Department of Life Science, Okayama University of Science, 1-1 Ridaicho, Kita, Okayama, Okayama, 700-0005, Japan

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Citation and License

Diagnostic Pathology 2010, 5:2 doi:10.1186/1746-1596-5-2

Published: 9 January 2010

Abstract

A rare case is presented of a 61-year-old man with a malignant peripheral nerve sheath tumor associated with neurofibromatosis type 1, with metastasis to the heart. The primary tumor originated in the right thigh in 1982. Since then, the patient has had repeated local recurrences in spite of repeated surgical treatment and adjuvant chemotherapy. He has developed previous metastases of the lung and heart. The patient died of cardiac involvement.