Table 4 |
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|
Results from multiple Cox regression analyses |
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|
Variable |
Hazard ratio |
95% Confidence interval |
P |
|
|
|||
|
c-erbB1 (clone EGFR.113) staining index |
1.076 |
0.92 to 1.26 |
0.37 |
|
Karnofsky performance status |
0.913 |
0.85 to 0.98 |
0.008 |
|
Gross total resection |
0.196 |
0.05 to 0.79 |
0.022 |
|
Age |
0.998 |
0.95 to 1.05 |
0.95 |
|
|
|||
|
c-erbB1 (clone EGFR.25) staining index |
0.991 |
0.80 to 1.23 |
0.93 |
|
Karnofsky performance status |
0.912 |
0.85 to 0.98 |
0.009 |
|
Gross total resection |
0.199 |
0.05 to 0.82 |
0.026 |
|
Age |
1.007 |
0.96 to 1.06 |
0.79 |
|
|
|||
|
c-erbB2 (clone CB11) staining index |
1.642 |
1.17 to 2.30 |
0.004 |
|
Karnofsky performance status |
0.854 |
0.78 to 0.94 |
0.001 |
|
Gross total resection |
0.324 |
0.08 to 1.38 |
0.13 |
|
Age |
0.973 |
0.92 to 1.03 |
0.36 |
|
|
|||
|
c-erbB2 (clone 5A2) staining index |
1.036 |
0.79 to 1.35 |
0.80 |
|
Karnofsky performance status |
0.910 |
0.85 to 0.98 |
0.009 |
|
Gross total resection |
0.186 |
0.05 to 0.78 |
0.021 |
|
Age |
1.005 |
0.96 to 1.06 |
0.85 |
|
|
|||
|
c-erbB2 (clone 3B5) staining index |
1.018 |
0.84 to 1.23 |
0.86 |
|
Karnofsky performance status |
0.912 |
0.85 to 0.98 |
0.009 |
|
Gross total resection |
0.190 |
0.05 to 0.77 |
0.020 |
|
Age |
1.006 |
0.96 to 1.06 |
0.81 |
|
|
|||
|
c-erbB3 (clone RTJ1) staining index |
0.975 |
0.83 to 1.15 |
0.76 |
|
Karnofsky performance status |
0.914 |
0.85 to 0.98 |
0.010 |
|
Gross total resection |
0.204 |
0.05 to 0.81 |
0.024 |
|
Age |
1.008 |
0.96 to 1.06 |
0.74 |
|
|
|||
|
c-erbB4 (clone HFR-1) staining index |
0.902 |
0.68 to 1.20 |
0.48 |
|
Karnofsky performance status |
0.907 |
0.85 to 0.97 |
0.005 |
|
Gross total resection |
0.178 |
0.05 to 0.72 |
0.015 |
|
Age |
1.003 |
0.96 to 1.05 |
0.90 |
|
|
|||
|
EGFR gene amplification |
0.689 |
0.23 to 2.11 |
0.51 |
|
Karnofsky performance status |
0.919 |
0.86 to 0.99 |
0.021 |
|
Gross total resection |
0.175 |
0.04 to 0.73 |
0.017 |
|
Age |
1.013 |
0.96 to 1.07 |
0.63 |
|
|
|||
|
Multiple Cox regression analyses were used to study the association between c-erbB1-4 expression and survival, adjusting for age at diagnosis, Karnofsky performance status scores, and extent of surgical resection. The association between EGFR amplification and survival was studied in the same manner. |
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|
Gulati et al. Diagnostic Pathology 2010 5:18 doi:10.1186/1746-1596-5-18 |
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