Table 3 |
||||||||
|
Immunohistochemical and FISH data |
||||||||
|
Case no. |
c-erbB-1 (clone EGFR.25) (internal domain) |
c-erbB-1 (clone EGFR.113) (external domain) |
c-erbB-2 (clone CB11) (internal domain) |
c-erbB-2 (clone 3B5) (internal domain) |
c-erbB-2 (clone 5A2) (internal domain) |
c-erbB-3 |
c-erbB-4 |
EGFR gene amplification (FISH) |
|
|
||||||||
|
1 |
9 |
9 |
4 |
6 |
6 |
9 |
4 |
Yes |
|
2 |
9 |
1 |
0 |
9 |
3 |
4 |
2 |
No |
|
3 |
6 |
0 |
4 |
3 |
1 |
9 |
0 |
No |
|
4 |
6 |
1 |
1 |
9 |
0 |
0 |
0 |
No |
|
5 |
0 |
0 |
4 |
6 |
2 |
6 |
4 |
No |
|
6 |
1 |
9 |
1 |
4 |
0 |
4 |
0 |
Yes |
|
7 |
9 |
9 |
0 |
1 |
0 |
0 |
0 |
No |
|
8 |
6 |
2 |
0 |
6 |
4 |
6 |
4 |
Yes |
|
9 |
9 |
9 |
2 |
6 |
0 |
6 |
6 |
No |
|
10 |
9 |
9 |
0 |
9 |
1 |
9 |
4 |
Yes |
|
11 |
4 |
0 |
2 |
6 |
0 |
4 |
4 |
Yes |
|
12 |
9 |
4 |
0 |
6 |
2 |
9 |
2 |
Yes |
|
13 |
9 |
2 |
4 |
6 |
1 |
9 |
2 |
No |
|
14 |
4 |
0 |
0 |
1 |
0 |
0 |
0 |
No |
|
15 |
2 |
1 |
0 |
9 |
1 |
6 |
0 |
No |
|
16 |
6 |
0 |
0 |
4 |
0 |
6 |
1 |
No |
|
17 |
9 |
2 |
0 |
9 |
4 |
9 |
2 |
No |
|
18 |
4 |
1 |
6 |
9 |
1 |
4 |
4 |
No |
|
19 |
4 |
0 |
0 |
1 |
0 |
4 |
0 |
Yes |
|
20 |
6 |
1 |
1 |
6 |
0 |
6 |
1 |
Yes |
|
21 |
6 |
4 |
1 |
6 |
0 |
4 |
2 |
No |
|
22 |
9 |
6 |
2 |
6 |
6 |
4 |
2 |
No |
|
23 |
9 |
3 |
0 |
6 |
0 |
1 |
0 |
No |
|
24 |
6 |
0 |
0 |
6 |
3 |
6 |
2 |
No |
|
25 |
6 |
2 |
1 |
6 |
3 |
9 |
2 |
No |
|
26 |
6 |
4 |
6 |
6 |
2 |
4 |
1 |
Yes |
|
27 |
6 |
0 |
0 |
1 |
0 |
2 |
1 |
No |
|
28 |
6 |
1 |
0 |
4 |
0 |
4 |
1 |
No |
|
29 |
9 |
6 |
0 |
4 |
0 |
0 |
1 |
No |
|
30 |
3 |
0 |
0 |
4 |
0 |
2 |
2 |
No |
|
31 |
6 |
1 |
0 |
9 |
3 |
9 |
6 |
No |
|
|
||||||||
|
Median Staining Index |
6 |
1 |
0 |
6 |
1 |
4 |
2 |
|
|
|
||||||||
|
No. of positive cases/Total no. of cases |
30/31 |
22/31 |
14/31 |
31/31 |
16/31 |
27/31 |
23/31 |
9/31 |
|
Percentage positivity |
97% |
71% |
45% |
100% |
52% |
97% |
74% |
29% |
|
|
||||||||
|
Gulati et al. Diagnostic Pathology 2010 5:18 doi:10.1186/1746-1596-5-18 |
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