Table 3

Immunohistochemical and FISH data

Case no.

c-erbB-1

(clone EGFR.25) (internal domain)

c-erbB-1

(clone EGFR.113) (external domain)

c-erbB-2

(clone CB11) (internal domain)

c-erbB-2

(clone 3B5) (internal domain)

c-erbB-2

(clone 5A2)

(internal domain)

c-erbB-3

c-erbB-4

EGFR gene amplification (FISH)


1

9

9

4

6

6

9

4

Yes

2

9

1

0

9

3

4

2

No

3

6

0

4

3

1

9

0

No

4

6

1

1

9

0

0

0

No

5

0

0

4

6

2

6

4

No

6

1

9

1

4

0

4

0

Yes

7

9

9

0

1

0

0

0

No

8

6

2

0

6

4

6

4

Yes

9

9

9

2

6

0

6

6

No

10

9

9

0

9

1

9

4

Yes

11

4

0

2

6

0

4

4

Yes

12

9

4

0

6

2

9

2

Yes

13

9

2

4

6

1

9

2

No

14

4

0

0

1

0

0

0

No

15

2

1

0

9

1

6

0

No

16

6

0

0

4

0

6

1

No

17

9

2

0

9

4

9

2

No

18

4

1

6

9

1

4

4

No

19

4

0

0

1

0

4

0

Yes

20

6

1

1

6

0

6

1

Yes

21

6

4

1

6

0

4

2

No

22

9

6

2

6

6

4

2

No

23

9

3

0

6

0

1

0

No

24

6

0

0

6

3

6

2

No

25

6

2

1

6

3

9

2

No

26

6

4

6

6

2

4

1

Yes

27

6

0

0

1

0

2

1

No

28

6

1

0

4

0

4

1

No

29

9

6

0

4

0

0

1

No

30

3

0

0

4

0

2

2

No

31

6

1

0

9

3

9

6

No


Median Staining Index

6

1

0

6

1

4

2


No. of positive cases/Total no. of cases

30/31

22/31

14/31

31/31

16/31

27/31

23/31

9/31

Percentage positivity

97%

71%

45%

100%

52%

97%

74%

29%


Gulati et al. Diagnostic Pathology 2010 5:18   doi:10.1186/1746-1596-5-18

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