Email updates

Keep up to date with the latest news and content from Diagnostic Pathology and BioMed Central.

Open Access Open Badges Short report

Ostial plication: a rarely reported cause of sudden death

Fabio De-Giorgio1* and Vincenzo Arena2

Author affiliations

1 Institute of Legal Medicine, Catholic University, School of Medicine, Rome, Italy

2 Institute of Pathologic Anatomy, Catholic University, School of Medicine Rome, Italy

For all author emails, please log on.

Citation and License

Diagnostic Pathology 2010, 5:15  doi:10.1186/1746-1596-5-15

Published: 25 February 2010


We report a rare case of ostial plication as a potential cause of sudden death. Very few reports and images are available in the specialized literature regarding this anomaly. Ostial plication may be a source of sudden death or cause of death when no other significant autopsy findings are present.

Ostial plication is a congenital severe obstruction/occlusion of the right or left ostium. Plication of the aortic wall leads to a "valve-like" ridge that can act as a door blocking inflow during diastolic filling, with consequent ischemia and a potentially life-threatening arrhythmia. The true incidence of this condition and its relationship to sudden death have not been reported in the literature. We believe that this case will be useful to autopsy pathologists in detecting this infrequent anomaly, thus providing a more accurate estimation of its incidence.