Principle of tissue on chip based mass spectrometry (toc-MS): (A) Head and neck cancer (HNC) tissue sections were stained H&E to obtain an overview of the tissue architecture. (B) Exemplary cutting lines of laser microdissection. (C) Stroma areas with about 100 square μm were cut out using the laser microdissection and transferred on a ProteinChip array (D). The same procedure was performed with normal connective tissue (not to scale).
Escher et al. Diagnostic Pathology 2010 5:10 doi:10.1186/1746-1596-5-10