Histological findings of the left fimbriated ende. (A) Low - power view shows lining of enlarged cells at fimbrial surface with slightly thickened stroma. (B) High - power view shows serous adenocarcinoma in micropapillary structure. (C and D) Tumor cells shows immunopositive for P53. Fig. 3C and 3D are from the same site. (E and F) So-called p53 signature is seen at the periphery of the left fimbrial ende. Fig. 3E and 3F are from the same site. As seen in the Inset of E, p53-positive cells are composed of seemingly, non-cancerous cells. [A; H&E, ×4, B; H&E, ×40, C: H&E, ×15, D; Immunohistochemistry for p53, ×15, E: H&E, ×10, F: Immunohistochemistry for p53, ×10].
Fukumura et al. Diagnostic Pathology 2009 4:43 doi:10.1186/1746-1596-4-43