Table 1 |
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|
Chronic changes noted in renal allograft biopsies of 2 groups, Ahmedabad Tolerance Induction Protocol (ATIP) vs. controls: |
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|
Biopsies |
ATIP |
Controls |
|
|
||
|
(n = 1151) |
(n = 974) |
(n = 177) |
|
|
||
|
|
||
|
Chronic changes (n = 135) |
107 (10.98%) |
31 (17.5%) |
|
|
||
|
Mean follow-up (months) (range) |
130.9 (23–277) |
151.9 (13.9–280) |
|
|
||
|
Male: female |
87:20:00 |
21:10 |
|
|
||
|
Hypertension (BP > 130/90 mm Hg) |
71 (66.4%) |
13 (41.9%) |
|
|
||
|
Proteinuria (24 hrs urine albumin > 800 mg) |
46 (43%) |
25(80.6%) |
|
|
||
|
HISTOPATHOLOGY |
||
|
|
||
|
Interstitial fibrosis+ tubular atrophy |
107 (100%) |
31 (100%) |
|
|
||
|
Focal global sclerosis |
50 (46.7%) |
21 (67.7%) |
|
|
||
|
Chronic transplant glomerulopathy |
35 (32.7%) |
15 (48.4%) |
|
|
||
|
C4d deposits |
2(1.9%) |
6 (19.4%) |
|
|
||
|
Acute on chronic calcineurin inhibitor toxicity |
77 (71.9%) |
15 (48.4%) |
|
|
||
|
Acute on chronic T/B cell rejection |
30 (28.1%) |
16 (51.6%) |
|
|
||
|
Patel et al. Diagnostic Pathology 2009 4:4 doi:10.1186/1746-1596-4-4 |
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