FISH analysis of 7q31 region. Case n° 10: a) FISH in bronchial biopsy section showing gain of both EGFR gene and chromosome 7 centromere; b) the patient is classified as amplified on the basis of eusomic status of 7q31 region. Case n° 2: c) FISH in pleural effusion sample with EGFR and centromere balanced aneusomy; d) increased copy number of 7q31 region is a signature of polysomy.
Casorzo et al. Diagnostic Pathology 2009 4:36 doi:10.1186/1746-1596-4-36