Table 2 |
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|
Immunohistochemical analysis of p16INK4A expression in tissue microarray cores from 806 cervix biopsies containing normal tissues, CIN1, CIN2, CIN3, and invasive cervical carcinoma (ICC), evaluated using the immunohistological score. |
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|
n |
p16INK4A immunostaining* |
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|
|
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|
0 |
2 |
3 |
4 |
5 |
6 |
7 |
8 |
||
|
|
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|
Normal |
10 |
7 (70.0) |
3 (30.0) |
0 (0) |
0 (0) |
0 (0) |
0 (0) |
0 (0) |
0 (0) |
|
CIN1 |
249 |
47 (18.9) |
22 (8.8) |
18 (7.2) |
35 (14.1) |
19 (7.6) |
20 (8.0) |
12 (4.8) |
76 (30.5) |
|
CIN2 |
233 |
10 (4,3) |
11 (4.7) |
14 (6.0) |
15 (6.4) |
13 (5.6) |
18 (7.7) |
7 (3.0) |
145 (62.2) |
|
CIN3 |
181 |
3 (1.7) |
0 (0) |
3 (1.7) |
3 (1.7) |
2 (1.1) |
3 (1.7) |
5 (2.8) |
162 (89.5) |
|
ICC |
133 |
2 (1.5) |
0 (0) |
2 (1.5) |
1 (0.8) |
1 (0.8) |
1 (0.8) |
3 (2.3) |
123 (92.5) |
|
|
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|
* Samples were assigned an immunohistological score (0 – 8) according to the intensity of staining and the proportion of stained cells in the cervical epithelium. The total score was the sum of score for stain intensity (0 – 3 points: 0 – no staining; 1 – weak staining; 2 points – moderate staining; and 3 – strong staining) and the score for propoertion of epithelial cells stained (0 – 5 points: 0 – no staining; 1 – <1% nuclei positive; 2 – 1% – 10% nuclei positive; 3 – 11% – 33% nuclei positive; 4 – 34% – 66% nuclei positive; and 5 – > 66% of nuclei positive). |
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|
Lesnikova et al. Diagnostic Pathology 2009 4:22 doi:10.1186/1746-1596-4-22 |
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