Table 2

Immunohistochemical analysis of p16INK4A expression in tissue microarray cores from 806 cervix biopsies containing normal tissues, CIN1, CIN2, CIN3, and invasive cervical carcinoma (ICC), evaluated using the immunohistological score.

n

p16INK4A immunostaining*


0

2

3

4

5

6

7

8


Normal

10

7

(70.0)

3

(30.0)

0

(0)

0

(0)

0

(0)

0

(0)

0

(0)

0

(0)

CIN1

249

47

(18.9)

22

(8.8)

18

(7.2)

35

(14.1)

19

(7.6)

20

(8.0)

12

(4.8)

76

(30.5)

CIN2

233

10

(4,3)

11

(4.7)

14

(6.0)

15

(6.4)

13

(5.6)

18

(7.7)

7

(3.0)

145

(62.2)

CIN3

181

3

(1.7)

0

(0)

3

(1.7)

3

(1.7)

2

(1.1)

3

(1.7)

5

(2.8)

162

(89.5)

ICC

133

2

(1.5)

0

(0)

2

(1.5)

1

(0.8)

1

(0.8)

1

(0.8)

3

(2.3)

123

(92.5)


* Samples were assigned an immunohistological score (0 – 8) according to the intensity of staining and the proportion of stained cells in the cervical epithelium. The total score was the sum of score for stain intensity (0 – 3 points: 0 – no staining; 1 – weak staining; 2 points – moderate staining; and 3 – strong staining) and the score for propoertion of epithelial cells stained (0 – 5 points: 0 – no staining; 1 – <1% nuclei positive; 2 – 1% – 10% nuclei positive; 3 – 11% – 33% nuclei positive; 4 – 34% – 66% nuclei positive; and 5 – > 66% of nuclei positive).

Lesnikova et al. Diagnostic Pathology 2009 4:22   doi:10.1186/1746-1596-4-22

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