Table 1

Immunohistochemical analysis of p16INK4A expression in tissue microarray cores from 806 cervix biopsies containing normal tissues, CIN1, CIN2, CIN3, and invasive cervical carcinoma (ICC), evaluated using the simple protocol.

p16INK4A immunostaining


n

Negative*

Positive#


Normal cervix

10

10 (100.0)

0 (0)

CIN1

249

69 (27.7)

180 (72.3)

CIN2

233

21 (9.0)

212 (91.0)

CIN3

181

3 (1.7)

178 (98.3)

ICC

133

2 (1.5)

131 (98.5)


*Negative: no staining or weak staining in less than 10% of epithelial cells.

#Positive: moderate or strong staining in more than 10% of epithelial cells.

Lesnikova et al. Diagnostic Pathology 2009 4:22   doi:10.1186/1746-1596-4-22

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