Figure 1.

Immunohistochemical analysis of p16^INK4A expression using monoclonal antibody clone JC8 in tissue microarray cores from cervix biopsies with normal epithelium (A, B), CIN1 (C, D), CIN2 (E, F), CIN3 (G, H) and invasive squamous carcinoma (I, J). The normal epithelial and stromal cells are negative (A – B). Strong, distinct, diffuse staining of both nuclei and cytoplasm is seen in the dysplastic/neoplastic epithelium (C – J).