Table 3

Common IF-ANA patterns associated with specific diseases

ANA pattern

Antigen

Associated diseases

Speckled

ENA, RNP, Sm, SSA/Ro, SSB/La, Scl-70, Jo-1, ribosomal-P

SLE, Mixed CTD, SS, Primary Sjogren's syndrome, PM

Homogenous

dsDNA, Histones

SLE, Drug induced SLE

Peripheral (rim)

RNP, Sm, SSA/Ro

SLE, SS

Nucleolar

Anti-PM-Scl, anti-RNA polymerase I-III, anti-U3-RNP, To RNP

SS, PM

Centromere

CENP A-E

Limited SS

Kumar et al. Diagnostic Pathology 2009 4:1   doi:10.1186/1746-1596-4-1