Table 1

Sensitivity and specificity of ANA and its clinically important subtypes [18,19]

Autoantibodies

Associated CTD

Sensitivity

Specificity


ANA

SLE

93

57

Sjogren's syndrome

48

52

SS

85

54

PM/dermatomyositis

61

63

Raynaud phenomena

64

41


Specific ANA

Anti-dsDNA

SLE

57

97

Anti-Sm

SLE

25–30

High*

Anti-SSA/Ro

Sjogren's syndrome, subacute cutaneous SLE, Neonatal lupus syndrome

8–70

87

Anti-SSB/La

Sjogren's syndrome, subacute cutaneous SLE, Neonatal lupus syndrome

16–40

94

Anti-U3-RNP

SS

12

96

Anticentromere

Limited cutaneous SS

65

99.9

Scl-70

SS

20

100

Jo-1

PM

30

95


* Precise data not available.

Kumar et al. Diagnostic Pathology 2009 4:1   doi:10.1186/1746-1596-4-1

Open Data