Antinuclear antibodies and their detection methods in diagnosis of connective tissue diseases: a journey revisited

doi:10.1186/1746-1596-4-1

Diagnostic Pathology

Volume 4

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Antinuclear antibodies and their detection methods in diagnosis of connective tissue diseases: a journey revisited

Yashwant Kumar¹ , Alka Bhatia² and Ranjana Walker Minz³

¹Department of Pathology and Laboratory Medicine, Grecian Superspeciality, Heart, Cancer and Multispeciality Hospital, Sector 69, Mohali, India

²Department of Experimental Medicine and Biotechnology, Post Graduate Institute of Medial Education and Research, Chandigarh, India

³Department of Immunopathology, Post Graduate Institute of Medial Education and Research, Chandigarh, India

author email corresponding author email

Diagnostic Pathology 2009, 4:1doi:10.1186/1746-1596-4-1


Published:	2 January 2009

Abstract

It has been more than 50 years since antinuclear antibodies were first discovered and found to be associated with connective tissue diseases. Since then different methods have been described and used for their detection or confirmation. For many decades immunofluorescent antinuclear antibody test has been the "gold standard" in the diagnosis of these disorders. However to increase the sensitivity and specificity of antinuclear antibody detection further approaches were explored. Today a battery of newer techniques are available some of which are now considered better and are competing with the older methods. This article provides an overview on advancement in antinuclear antibody detection methods, their future prospects, advantages, disadvantages and guidelines for use of these tests.